ACUTE EFFECTS ON BONE-MARROW AFTER ASSOCIATION BETWEEN RADIOSENSITIZER AND X-RAYS - NN/N METHOD

A histopathological and morphometric study was performed in the bone marrow of mice after association of cisdiamminedi-chloroplatinum II (3.0 mg/kg) plus X-rays (103.20 mC/kg - 400R). Estimation of bone marrow effects was assessed by counting the number of non nucleated-erythrocytes (NN) and nucleated (N) cells, and establishing (NN/N) ratio.The morphomeric method used correlates and makes possible quantification of histopathologic changes of bone marrow through relation of vascular stroma and cellular parenchyma. It can be used as a biological dosimetry parameter and to estimate injury and recovery of hematologic evolution of different myelotoxic agents.ESCOLA PAULISTA MED,DEPT MED RADIOTERAPIA RADIOBIOL,RUA BOTUCATU 740,900 VILA CLEMENTINO,BR-04023 SAO PAULO,BRAZILESCOLA PAULISTA MED,DEPT MED RADIOTERAPIA RADIOBIOL,RUA BOTUCATU 740,900 VILA CLEMENTINO,BR-04023 SAO PAULO,BRAZILWeb of Scienc