Improvement of bronchial hyperresponsiveness in asthmatic children treated for concomitant sinusitis

Background: There appears to be an association between sinusitis and asthma. The effect on bronchial hyperresponsiveness of clinical therapy for sinusitis in children may help to decipher whether sinusitis and asthma are independent manifestations of the same disease.Objective: To evaluate the effect of clinical treatment fur sinusitis in patients with rhinitis and/or asthma on symptoms and on bronchial hyperresponsiveness to methacholine.Methods: Open label, randomized, non-treatment control in a teaching hospital in Sao Paulo, Brazil. Forty-six atopic and 20 normal children were studied. The atopic children consisted of 18 with allergic rhinitis (12 without sinusitis and 6 with sinusitis), and 28 children with rhinitis with asthma (13 with normal sinus radiographs and 15 with complete opacification of the maxillary sinuses). Methacholine PC20 was determined before and 30 days after treatment with nasal saline, sulfamethoxazole-trimethoprim, antihistamine/decongestant, and five days of prednisone. Sinus radiographs were also repeated.Results: The only patients with increase in methacholine PC20 were patients with rhinitis and asthma with opacified maxillary sinuses at entry and who at 30 days had normal sinus radiographs (P <.05).Conclusion: In this study, children with allergic rhinitis and sinusitis with asthma improved their bronchial hyperresponsiveness to methacholine and decreased their symptoms with appropriate response of their sinuses to clinical therapy.ALLERGY RES FDN,LOS ANGELES,CA 90025UNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT PEDIAT,DIV RHEUMATOL ALLERGY & CLIN IMMUNOL,SAO PAULO,BRAZILUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT PEDIAT,DIV RHEUMATOL ALLERGY & CLIN IMMUNOL,SAO PAULO,BRAZILWeb of Scienc