Evaluación de la actividad antitumoral in vitro de compuestos naturales en el cáncer de próstata

8 páginas.- Trabajo Fin de GradoIsothiocyanates (ITCs), natural compounds found in several vegetables, have demonstrated some chemopreventive and anti-cancer activities both under in vitro and in vivo conditions. In this study, we assayed the effects of 2 ITCs found in turnip tops grown in Galicia, PTC and 4PI, that were not previously tested on cancer models, on the survival and proliferation of cultured PC-3 and DU-145 prostate cancer (PCA) cells in the presence or in absence of anti-cancer drug docetaxel. Our results show that PTC inhibited in a significant manner the viability of PCA cells at different interval (24, 48 and 72 h) in a dose-dependent manner. Furthermore, this compound potentiated the effects of docetaxel on both parameters in a significant manner. On the contrary, 4PI showed no effect. These results let us hypothesize that PTC may find use in the treatment of human prostate cancers, both as chemopreventive and anti-cancer drugs, and can result in nutritional recommendations for cancer patients.Peer reviewe