Inherently Chiral Resorcin[4]arenes: A New Concept for Improving the Functionality

Wiegmann S, Mattay J. Inherently Chiral Resorcin[4]arenes: A New Concept for Improving the Functionality. Organic Letters. 2011;13(12):3226-3228.A new reactive postion at the upper rim of inherently chiral resorcin[4]arenes was introduced through cleavage of an up to now unreactive methoxy group through the demethylating reagent 9-I-9-BBN. Conservation of the inherent chirality was warranted through the use of a protecting group at the free phenol group