Ciljevi istraživanja: Razviti metodu za kvalitativno i kvantitativno određivanje metadona i EDDP-a u biološkim uzorcima korištenjem HPLC tehnike, koja se može primijeniti u stvarnoj praksi određivanja nepoznate koncentracije metadona u pacijenata na supstitucijskoj terapiji metadonom. Materijali i metode: Metodom HPLC su analizirane standardne otopine metadona i EDDP-a, pripremljene razrjeđivanjem standarda metadona i EDDP-a (Lipomed) te otopine Heptanona u metanolu. Nakon što su metadon i EDDP detektirani u standardnim otopinama te nakon ekstrakcije oba analita iz seruma korištenjem tehnike LLE (engl. liquid-liquid extraction), ekstrahirani analiti (smjesa metadona i EDDP-a) su u koncentraciji od 1 mg/L i volumenu od 10 µL injektira...
A simple method for analysis of methadone and its two main metabolites EDDP and EMDP in hair was dev...
During validation of a gas chromatography-mass spectrometry (GC-MS) method for the methadone metabol...
A stereoselective analysis of methadone (Mtd) in whole blood and serum was developed using liquid ch...
Ciljevi istraživanja: Razviti metodu za kvalitativno i kvantitativno određivanje metadona i EDDP-a u...
The aim of this study was to determine the optimal biological sample and the optimal extraction tech...
Restricted access materials (RAM) which allow direct injection of biological fluids in a chromatogra...
A bioanalytical method was developed for the quantitation of methadone (MTD) and its primary metabol...
Objective: To develop method to measure both methadone enantiomers and its major metabolite 2-ethyli...
Gas chromatography–mass spectrometry quantitative method was developed to monitor concentrations of ...
Methods for analysis of methadone and its principal metabolite, 2-ethylidene-l,5-dimethyl-3,3-diphen...
[[abstract]]A liquid chromatography-photodiode array (LC-PDA) method using a chiral analytical colum...
Metadon je sintetski opioid koji se danas primarno koristi kao supstitucijska terapija u liječenju o...
Opioid replacement therapy with long-acting opioids is the most effective approach to counteract her...
A novel test has been developed for the analysis of methadone in dried blood spot specimens from pat...
ABSTR ACT: This study aimed to develop a solid-phase extraction gas chromatography-selected ion moni...
A simple method for analysis of methadone and its two main metabolites EDDP and EMDP in hair was dev...
During validation of a gas chromatography-mass spectrometry (GC-MS) method for the methadone metabol...
A stereoselective analysis of methadone (Mtd) in whole blood and serum was developed using liquid ch...
Ciljevi istraživanja: Razviti metodu za kvalitativno i kvantitativno određivanje metadona i EDDP-a u...
The aim of this study was to determine the optimal biological sample and the optimal extraction tech...
Restricted access materials (RAM) which allow direct injection of biological fluids in a chromatogra...
A bioanalytical method was developed for the quantitation of methadone (MTD) and its primary metabol...
Objective: To develop method to measure both methadone enantiomers and its major metabolite 2-ethyli...
Gas chromatography–mass spectrometry quantitative method was developed to monitor concentrations of ...
Methods for analysis of methadone and its principal metabolite, 2-ethylidene-l,5-dimethyl-3,3-diphen...
[[abstract]]A liquid chromatography-photodiode array (LC-PDA) method using a chiral analytical colum...
Metadon je sintetski opioid koji se danas primarno koristi kao supstitucijska terapija u liječenju o...
Opioid replacement therapy with long-acting opioids is the most effective approach to counteract her...
A novel test has been developed for the analysis of methadone in dried blood spot specimens from pat...
ABSTR ACT: This study aimed to develop a solid-phase extraction gas chromatography-selected ion moni...
A simple method for analysis of methadone and its two main metabolites EDDP and EMDP in hair was dev...
During validation of a gas chromatography-mass spectrometry (GC-MS) method for the methadone metabol...
A stereoselective analysis of methadone (Mtd) in whole blood and serum was developed using liquid ch...