This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of cyclosporin A (CsA) and, if so, to determine the molecular mechanisms involved. The effect of MPA treatment on CsA-induced signaling through the transforming growth factor-beta (TGF-beta)/Smad pathway was evaluated by immunoblot analysis in cultured primary rat mesangial cells. Treatment of cells with 1 mu mol/l MPA did not significantly decrease the CsA-induced expression of TGF-beta(1), but partially reversed the increases in Smad3 phosphorylation and fibronectin (FBN) production, and increased Smad7 expression. These results suggest that MPA may ameliorate CsA-induced FBN production by modulating the Smad signaling pathway. This study pro...
Mycophenolic acid (MPA) appears to have anti-fibrotic effects, but the molecular mechanisms underlyi...
PURPOSE: Excess proliferation of mesenchymal cells such as vascular smooth muscle cells and glomerul...
Inhibition of the matrix metalloproteinase system in a rat model of chronic cyclosporine nephropathy...
This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of...
This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of...
This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of...
Mycophenolic acid antagonizes the activation of cultured human mesangial cells.BackgroundActivation ...
Mesangial cell (MC) proliferation and extracellular matrix (ECM) accumulation are major pathologic f...
Mycophenolic acid antagonizes the activation of cultured human mesangial cells.BackgroundActivation ...
BACKGROUND AND PURPOSE Renal fibroblasts play a pivotal role in the development of tubulointerstitia...
The synthesis of extracellular matrix (ECM) in mesangial cells (MCs) plays important roles in the de...
Mycophenolic acid (MPA) was introduced into clinical practice as immunosuppressive drug therapy to p...
Purpose: Excess proliferation and extracellular matrix (ECM) accumulation of mesenchymal cells such ...
Mycophenolic acid (MPA) appears to have anti-fibrotic effects, but the molecular mechanisms underlyi...
Mycophenolic acid (MPA) appears to have anti-fibrotic effects, but the molecular mechanisms underlyi...
Mycophenolic acid (MPA) appears to have anti-fibrotic effects, but the molecular mechanisms underlyi...
PURPOSE: Excess proliferation of mesenchymal cells such as vascular smooth muscle cells and glomerul...
Inhibition of the matrix metalloproteinase system in a rat model of chronic cyclosporine nephropathy...
This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of...
This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of...
This study was undertaken to determine if mycophenolic acid (MPA) inhibits the profibrotic action of...
Mycophenolic acid antagonizes the activation of cultured human mesangial cells.BackgroundActivation ...
Mesangial cell (MC) proliferation and extracellular matrix (ECM) accumulation are major pathologic f...
Mycophenolic acid antagonizes the activation of cultured human mesangial cells.BackgroundActivation ...
BACKGROUND AND PURPOSE Renal fibroblasts play a pivotal role in the development of tubulointerstitia...
The synthesis of extracellular matrix (ECM) in mesangial cells (MCs) plays important roles in the de...
Mycophenolic acid (MPA) was introduced into clinical practice as immunosuppressive drug therapy to p...
Purpose: Excess proliferation and extracellular matrix (ECM) accumulation of mesenchymal cells such ...
Mycophenolic acid (MPA) appears to have anti-fibrotic effects, but the molecular mechanisms underlyi...
Mycophenolic acid (MPA) appears to have anti-fibrotic effects, but the molecular mechanisms underlyi...
Mycophenolic acid (MPA) appears to have anti-fibrotic effects, but the molecular mechanisms underlyi...
PURPOSE: Excess proliferation of mesenchymal cells such as vascular smooth muscle cells and glomerul...
Inhibition of the matrix metalloproteinase system in a rat model of chronic cyclosporine nephropathy...