Preparation and characteristics of quercetin-loaded chitooligosaccharide nanoparticles and their incorporation into hydrogel for improving antioxidant activity

????????? ???????????? ?????? ????????????(QUE)??? ???????????? ??????????????????(IQUE)??? ????????? ????????? ???????????? ??????????????? ?????? ??? ????????? ?????? ????????? ?????? ????????? ???????????? ????????????. ????????? ??????????????? ???????????? ?????????, ?????? ??????????????? ??? ????????? ????????? ?????? ??????????????? ????????? ???????????? ????????? ????????? ?????? ??????????????? ??????????????????. ????????? ??? ????????? ????????? ?????? ???????????? ?????? QUE ??? IQUE??? ????????? ??? ????????? ????????? ???????????????, ?????? ????????? ?????? ?????? ?????? ????????? ????????? ??????????????? ?????????. ?????? ????????? ??????????????????(COS)??? ??????-??????????????????(PGA)??? ?????? ????????? ?????? ????????? ???????????? ?????? ??????(ionic gelation)??? ?????? ???????????????. COS/PGA ?????? ????????? COS ????????? ???????????? ?????? ????????? ????????? ?????? ????????? ???????????????. ??????, QUE??? IQUE??? ????????? ?????? ??????(QUE NPDs, IQUE NPDs)??? 150 nm??? ?????? ????????? ???????????????, ?????? ????????? ????????? 160 ??M ??? ??? ?????? ???????????? ?????? ???????????????. QUE NPDs??? IQUE NPDs??? ????????? ????????? QUE ??? IQUE ?????? ?????? 137%??? 223% ?????? ????????? ?????? ?????? ???????????? ?????? ????????? ????????? ?????? ????????? ???????????????. ?????? ????????? ????????? ????????? ?????? ????????? ????????? QUE NPDs??? IQUE NPDs??? ????????? ????????? ?????? QUE NPDs ??? IQUE NPDs?????? ?????? 125% ??? 124% ?????? ????????? ????????? ?????? ????????? ?????? ?????? ????????? ????????? ?????? ????????? ???????????????. ?????? ????????? ????????? ????????? ?????? ????????? ????????? QUE??? IQUE??? ???????????? ?????? G??? ??? Tm value??? ???????????????. ??????, QUE NPDs??? ????????? ????????? ????????? G??? value??? ethanol 10% ????????? ???(E10)?????? 206% ???????????? ??? ????????? ?????? ????????? ?????? ???????????????. ??????, QUE??? IQUE ??? QUE NPDs??? IQUE NPDs??? ????????? ?????? ????????? ????????? ?????? ???????????????. ??????, QUE NPDs??? ????????? ????????? ?????? ????????? ???????????? ????????? ???????????? ???????????????(p>0.05). ?????????, ??? ??????????????? ????????? ????????? ????????? QUE??? IQUE??? ?????? ????????? ???????????? ????????? ????????? ???????????? ??? ????????????, ?????? ????????? ?????? ?????? ?????? ????????? ????????? ?????? ????????? ???????????????.Maste