The binding of vascular endothelial growth factor (VEGF) to its receptors stimulates tumor growth; therefore, modulation of VEGF would be a viable approach for antiangiogenic therapy. We constructed a series of soluble decoy receptors containing different VEGF receptor 1 (FLT1) and VEGF receptor 2 (KDR) extracellular domains fused with the Fc region of human immunoglobulin (lg) and evaluated their antiangiogenic effects and antitumor effects. Results of in vitro binding and cell proliferation assays revealed that decoy receptor FP3 had the highest affinity to VEGF-A and -B. Compared with bevacizumab, FP3 more effectively inhibited human umbilical vein endothelial cell (HUVEC) migration and vessel sprouting from rat aortic rings. FP3 signifi...
Although the function of vascular endothelial growth factor in the induction of tumor angiogenesis i...
Although the function of vascular endothelial growth factor in the induction of tumor angiogenesis i...
Vascular endothelial growth factor (VEGF) is known to play a predominant role in tumor angiogenesis ...
Various ways to inhibit vascular endothelial growth factor (VEGF), a key facilitator in tumor angiog...
Two vascular endothelial growth factor (VEGF) receptors, FLT-1 and KDR, are expressed preferentially...
Vascular endothelial growth factor receptor 3 (VEGFR-3) binds VEGF-C and VEGF-D and is essential for...
Angiogenesis is defined as the development of blood vessels from a pre-existing vasculature and has ...
Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor ...
Background Tumor growth depends on pro-angiogenic vascular endothelial growth factors (VEGF-A/-B) vi...
Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor ...
Background Tumor growth depends on pro-angiogenic vascular endothelial growth factors (VEGF-A/-B) vi...
Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor ...
Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor ...
Angiogenesis is one of the key acquired characteristics or “hallmarks” essential for the growth and ...
Angiogenesis is one of the key acquired characteristics or “hallmarks” essential for the growth and ...
Although the function of vascular endothelial growth factor in the induction of tumor angiogenesis i...
Although the function of vascular endothelial growth factor in the induction of tumor angiogenesis i...
Vascular endothelial growth factor (VEGF) is known to play a predominant role in tumor angiogenesis ...
Various ways to inhibit vascular endothelial growth factor (VEGF), a key facilitator in tumor angiog...
Two vascular endothelial growth factor (VEGF) receptors, FLT-1 and KDR, are expressed preferentially...
Vascular endothelial growth factor receptor 3 (VEGFR-3) binds VEGF-C and VEGF-D and is essential for...
Angiogenesis is defined as the development of blood vessels from a pre-existing vasculature and has ...
Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor ...
Background Tumor growth depends on pro-angiogenic vascular endothelial growth factors (VEGF-A/-B) vi...
Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor ...
Background Tumor growth depends on pro-angiogenic vascular endothelial growth factors (VEGF-A/-B) vi...
Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor ...
Vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase transmembrane receptor ...
Angiogenesis is one of the key acquired characteristics or “hallmarks” essential for the growth and ...
Angiogenesis is one of the key acquired characteristics or “hallmarks” essential for the growth and ...
Although the function of vascular endothelial growth factor in the induction of tumor angiogenesis i...
Although the function of vascular endothelial growth factor in the induction of tumor angiogenesis i...
Vascular endothelial growth factor (VEGF) is known to play a predominant role in tumor angiogenesis ...