Add to ORKGPrevious research demonstrated excessive decreases in reward sensitivity and increases in harm avoidance in depressed individuals. These results straightly lead to a hypothesis that depressed patients should avoid novelty or express reduced novelty-seeking behavior. Nevertheless, literature in this regard is inconsistent. Furthermore, whether the potentially altered novelty-associated behavior is dependent on changed anxiety/fear or related to altered goal-directed approaching tendency is unclear. Here, we tested novel object-approaching behavior in a free-exploration paradigm in chronic mild stress (CMS)-induced anhedonic and stress-resistant rats respectively. Other CMS-induced, emotional behaviors were also examined in a battery of behav...
RATIONALE: Negative affective states, e.g., anhedonia, are suggested to be involved in the long-last...
Previous work has shown that systematic individual differences between male Wistar rats can be detec...
Reduced capacity to experience pleasure, also known as anhedonia, is a key feature of the depressive...
Previous research demonstrated excessive decreases in reward sensitivity and increases in harm avoid...
BACKGROUND: In a substantial proportion of depressed patients, stressful life events play a role in ...
Depression is the most common form of mental disability in the world. Depressive episodes may be pre...
We used animal models of "forced swim stress" and "chronic unpredictable stress", and tried to revea...
We used animal models of "forced swim stress" and "chronic unpredictable stress"...
Anhedonia, the lost of interest or pleasure in normally enjoyable activities, is a core clinical fea...
RATIONALE: Impulsivity is a vulnerability marker for drug addiction in which other behavioural trait...
Chronic stress, in particular chronic psychosocial stress, is a risk factor in the aetiology of vari...
In order to develop a model for a depression-like syndrome in mice, we subjected male C57BL/6 mice t...
In a substantial proportion of depressed patients, stressful life events play a role in triggering t...
Anhedonia, the reduced ability to experience pleasure, is a dimensional entity linked to multiple ne...
Anhedonia, the reduced ability to experience pleasure, is a dimensional entity linked to multiple ne...
RATIONALE: Negative affective states, e.g., anhedonia, are suggested to be involved in the long-last...
Previous work has shown that systematic individual differences between male Wistar rats can be detec...
Reduced capacity to experience pleasure, also known as anhedonia, is a key feature of the depressive...
Previous research demonstrated excessive decreases in reward sensitivity and increases in harm avoid...
BACKGROUND: In a substantial proportion of depressed patients, stressful life events play a role in ...
Depression is the most common form of mental disability in the world. Depressive episodes may be pre...
We used animal models of "forced swim stress" and "chronic unpredictable stress", and tried to revea...
We used animal models of "forced swim stress" and "chronic unpredictable stress"...
Anhedonia, the lost of interest or pleasure in normally enjoyable activities, is a core clinical fea...
RATIONALE: Impulsivity is a vulnerability marker for drug addiction in which other behavioural trait...
Chronic stress, in particular chronic psychosocial stress, is a risk factor in the aetiology of vari...
In order to develop a model for a depression-like syndrome in mice, we subjected male C57BL/6 mice t...
In a substantial proportion of depressed patients, stressful life events play a role in triggering t...
Anhedonia, the reduced ability to experience pleasure, is a dimensional entity linked to multiple ne...
Anhedonia, the reduced ability to experience pleasure, is a dimensional entity linked to multiple ne...
RATIONALE: Negative affective states, e.g., anhedonia, are suggested to be involved in the long-last...
Previous work has shown that systematic individual differences between male Wistar rats can be detec...
Reduced capacity to experience pleasure, also known as anhedonia, is a key feature of the depressive...