Background Gender differences in life expectancy (LE) have been traditionally large in Central and Eastern Europe (CEE), and alcohol has been hypothesized to be one of its main determinants. We examined the role of alcohol in gender differences in LE in Estonia, Lithuania, Latvia, Moldova, Poland, Romania, Russia and Ukraine, and changes in this role from 1965 until 2012. Methods We decomposed the gender differences in LE at birth into alcohol- and non-alcohol-related mortality. We examined causes of death wholly attributable to alcohol over the whole period, and estimated from 1990 onwards additional alcohol-attributable mortality by using alcohol-attributable fractions from the Global Burden of Disease study. Results In the eight CEE coun...