Evaluation of Anti-hyperglycemic Effects of Methanolic Extract of Cinnamomum Zeylanicum in Laboratory Animal Models

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.Our present studies were focused on the probable anti-diabetic activity of the plant “Cinnamomum zeylanicumon” in laboratory animals and the statistical significance of such effect. The plant extract was subjected to assessment of gastrointestinal motility and anti-diabetic study through assessing Disaccharidase activity and six segment method which was performed to assess the amount of sucrose remaining in the GIT at six different positions. In the GI motility test, the extract showed laxative effect, which results the decreased absorption in small intestine. In Six Segment test, the amount of sucrose unabsorbed in different GIT segments were evaluated in control rats vs. rats fed with 500mg/kg extract at 30 minutes, 1hour, and 2hour. In Dissacharide activity the amount of unabsorbed sucrose in Pancreatic Enzymes are evaluated in control rats vs rats fed with 500mg/kg extract .The extract caused a significant, dose dependent inhibition of glucose absorption and showed hypoglycemic effects in Long-Evans rats weighing about 100-200 gm. The anti-diabetic effects were estimated by measuring the amount of glucose in the samples collected after the experiment. In conclusion, these observations provide evidence and possible mechanisms of action for the anti-diabetic properties of plant “Cinnamomum zeylanicumon” claimed in Ayurveda medicine