Evaluation of Anti-ulcerant Effect of Oroxylum Indicum in Ulcerative Rat Model at High Dose

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.The medicinal plants signify a massive basis of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Oroxyllum indicum is one of the medicinal plants that show anticancer, anti-ulcer, antidysenteric, antimicrobial, and anti-inflammatory activity. Various part of this plant is used in medical purpose. Alkaloids, glycocides, terpinoids, steroids, flavanoids, phenolics, tannins, anthraquinone, Coumarins etc. component has been found in this plant extract that show different therapeutic effects. In this project we investigated the methanolic extract of bark of Oroxylum indicum for anti-ulcer activity. To identify the plant`s therapuetic effects we conducted anti-ulcer and histopathology tests. The anti-ulcer activity of methanol extract of O. indicum bark was evaluated as doses of 200mg/kg and 400 mg/kg p.o while using omeprazole (20mg/kg,p.o) as the standard drug. Ulcer was induced by feeding 25ml/kg of ethanol (0.3M HCL in 60% ethanol). Gastric mucosa from the different groups were examined for ulcers by magnifying lens and scoring ulcer. For these experiments long evans rat were used. O. indicum is highly significant (P< 0.01) in protection of ethanol-induced ulcer, it showed protection of 73% and 76% at doses 200mg/kg/day and 400 mg/kg/day, p.o. respectively. These findings were further supported by the histological study. The investigation suggests that methanolic extract of O. indicum bark possess anti-ulcer activity