Determination of Analgesic Activity of Two Medicinal Plants of Bangladesh

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.Methanol extract of bark and leaves of Stereospermum chelonoides (SCBM & SCLM) and chloroform and pet ether extract from Ixora coccinea (ICC & ICPE) was assessed for analgesic properties on animal (mice) models. Administration of SCBM, SCLM and ICC, ICPE produced significant (p <.05), dose-dependent analgesic effect in formalin-induced the biting and licking in mice, suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response. In the current study, Ibuprofen was used as the standard analgesic drug. From the result it was found that, the SCBM inhibition 47.95 % and 47.62 % at doses of 250 mg/kg and 500 mg/kg respectively, SCLM inhibition 23.20 % and 31.05 % at doses of 250 mg/kg and 500 mg/kg respectively. On other hand extract of ICC inhibition 10.09% and 31.05% at the doses of 200 mg/kg and 400 mg/kg respectively and extract of ICPE gave 23.20% and 26.27% inhibition at the doses of 200 mg/kg and 400 mg/kg respectively. The standard group gives 58.19% of inhibition (p˂0.05)