A Study on Effects of Acacia Nilotica on Inhibition of Disaccharidase Activity in Long Evans Rats

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.Our present studies were focused on the probable anti-diabetic activity of the plant Acacia Nilotica in laboratory animals and the statistical significance of such effect. The plant extract was subjected to anti-diabetic study through assessing Disaccharidase activity and six segment method which was performed to assess the amount of sucrose remaining in the GIT at six different positions. In Six Segment test, the amount of sucrose unabsorbed in different GIT segments were evaluated in control rats vs. rats fed with 100mg/kg extract at 30 minutes, 1hour, and 2hour. In Dissacharidase activity the amount of unabsorbed sucrose in Pancreatic Enzymes are evaluated in control rats vs rats fed with 100mg/kg extract .The extract caused a significant (p