Determination of Analgesic Activity of the Leaves of Stereospermum chelonoides DC

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, BangladeshStereospermum chelonoides (Family: Bignoniaceae), locally known as ‘Dhamara’, is a medicinal herb, which is traditionally been used in various ailments like infections, rheumatism and inflammation, and also cancer. But till to date, very few investigations have been made for the scientific and methodical validation of these traditional claims. Therefore, the present study was designed to investigate analgesic property of methanol and petroleum ether fractions of the leaves of Stereospermum chelonoides DC. Analgesic potential of methanol and petroleum ether fractions of the leaves of Stereospermum chelonoides was evaluated for peripheral pharmacological actions using acetic acid-induced writhing. Both the fraction, at the doses of 250 mg/kg and 500 mg/kg, displayed significant analgesic action acid in a dose dependent manner in the tested models by inhibiting pain induced by acetic and the result was statistically significant. Indomethacin was used as the standard drug in this research. From the result it was found that, the methanol extract gives inhibition 8.36 % and 51.51 % at doses of 250 mg/kg and 500 mg/kg respectively and extract of petroleum ether gives 10.03% and 31.44% inhibition at the doses of 250 mg/kg and 500 mg/kg respectively. The standard group gives 86.96% of inhibition (p˂0.001)