Study of Pharmacological Activities of methanolic Extract of of Stephania japonica

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.Purpose: The research work was carried out to determine the pharmacological activities of methanolic extract of Stephania japonica Bark. Method: Methanolic bark extract was administered orally to the animal model (Swiss albino) and the effects were determined by comparing with respect to control group which were treated with 5% CMC.. Different experiments were used to determine the pharmacological profile which was Collected from internationally published publications and journals. Result: The plant was found to have depressive and carcinogenic effect. The CNS activity was evaluated by open field method and hole board test. In the open field method and hole board experiment the crude extract of Stephania japonica (200mg/kg, 400mg/kg & 800mg/kg) dose dependently reduces the number of peripheral locomotion, central locomotion and leaning in the open field test and reduces the number of head dipping and head poking in the hole board test. The reduction is significant (***p