Impact of Different Supplrment Drugs on Dissolution Profile pf Ranitidine (ZANTAC AND NEOTACK)

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) in East West University, Dhaka, Bangladesh.This work was proposed to determine the impact of different supplement drugs on the dissolution of Ranitidine. Here two brands of Ranitidine tablets were used, Zantac (GlasoSmithKine) and Neotack(Square). Weight variation test, hardness test, thickness test, dissolution of individual Ranitidine(Zantac and Neotack) and dissolution of Ranitidine(Zantac and Neotack) with different supplements were used as the parameters for the determination of impact on dissolution of different supplements on the dissolution of Ranitidine(Zantac and Neotack).The supplements used in this research work were Calbo (Calcium Supplement), Aristcal D (Calcium and vitamin D supplement), Acical-M (Calcium, vitamin D and Multimineral supplement), Nutrum Gold (Multivitamin and Multimineral supplement), Filwel Silver (Multivitamin and Multimineral supplement). UV Spectroscopy method was used. Distilled water was used as the dissolution medium. Dissolution tests were run for an hour and the samples were taken and diluted after 20, 40, 60 minutes and absorbance of the diluted samples were taken, by putting the value of the absorbance in the equation of the standard curve percent dissolved amount of the tablets were calculated. After an 60 minutes the percent dissolved amount of individual Zantac, Zantac with Calbo , Aristocal D, Acical-M, Nutrum Gold and Filwel Silver were 94.09%, 47.84%, 72.6%, 48.47%, 94.27% and 97.22% respectively. The percent dissolved amount of individual Neotack, Calbo ,Aristocal D, Acical-M, Nutrum Gold and Filwel Silver were 97.4%, 46.09%, 50.22%,74.6%,98.31%,99.11% respectively after an hour. The study result showed that Calbo and Acical M has highly significant impact, Aristocal D has moderate impact and Filwel Silver and Nutrum Gold has less significant impact on the dissolution of Ranitidine(Zantac and Neotack)