Influence of Omeprazol and Ramipril on In-Vitro Dissolution of Atorvastatin 10 mg Tablet with To Determine the Drug-Drug Interaction

This thesis submitted in partial fulfillment of the requirements for the degree of Bachelor of Pharmacy (B.Pharm) of East West University, Dhaka, Bangladesh.The main objective of this study was to determine the change of pharmacokinetic property; specially dissolution of Atorvastatin when it’s taken with combination of two drugs; Ramipril and Omeprazol. Atorvastatin is a widely used lipid lowering drug which is usually prescribed with various drugs like Omeprazol, Ramipril, Metformin, Multivitamin etc usually after dinner, what came out in some recent prescriptions collected before the study. Famous brand of these drugs were used, as in Lipicon 10mg for Atorvastatin, Ramoril 2.5mg for Ramipril, Cosec 20mg for Omeprazol so that a standard value of percent dissolution can be achieved. First the dissolution profile of Atorvastatin individually was studied going through the standard in-vitro dissolution test then the same procedure was run using Atorvastatin, Ramipril and Omeprazol in combination. However, it was found out from the study that Atorvastatin showed a greater percent of dissolution when taken with combination of those drugs than that of only Atorvastatin. From time range of 5min to 30min dissolution rate of Atorvastatin increased gradually. After 5min, 10min, 15min and 30min dissolution rate of atorvastatin was 2.093%,2.64%,7.01 %,36.14% respectively, and for the combination these were 5.063%,11.872%,32.38%,63.641% respectively. It means that if patients take Atorvastatin along with Ramipril and Omeprazol at a time, dissolution rate of Atorvastatin increases