Effect of Ethanol Extract Sambiloto Leaf (Andrographidis Folium) Against Blood Glucose Level in Male Swiss Webster Mice Induced by Aloxan Compared to Jamu D

 Introduction: Jamu D is Indonesian traditional medicine containing ethanol extract of sambiloto leaf (EESL) which can be used as diabetes mellitus alternative drug. The aim of this study is to know the effect of EESL in lowering blood glucose levels comparde to Jamu D. Methods :The real prospective experimental comparative with complete randomized design was done. Twenty four aloxan induced diabetic male Swiss Webster mice was divided into 6 groups of treatment i.e. EESL dose 1 (29.25 mg/ kgBW), EESL dose 2 (58.5 mg/ kgBW), EESL dose 3 (117 mg/ kgBW),  control (CMC 1% suspension), comparator (Glibenklamid 0.65 mg/ kgBW), Jamu D (195 mg/ kgBW) for 7 days. The fasting blood glucose level was examined at the eight day and blood glucose level decrease percentage was analyzed with ANOVA, continued with Tukey HSD, a = 0.05. Results: showed that the decrease of blood glucose level in EESL dose1(65.93 %), dose (66.66 %), was same with Jamu D (59.82 %)(p >0,05) while the decrease percentage in dose 2 was significant different with Jamu D (p < 0,01). Conclusions :  EESL dose 1 and dose 3 were as effective as Jamu D in decreasing blood glucose level while dose 2 was not effective&nbsp