Effect of Physalis Minina, Linn, Psidium Guajava, Linn., Sweitenia Mahagoni, Jacq Ethanol Extract Against Blood Glucose Level

Introduction: Diabetes mellitus (DM) is a group of metabolic disorder that is characterized by hyperglycemia due to insulin secretion or function disorder. Physalis minina, Linn., Psidium guajava, Linn., Sweitenia mahagoni, Jacq are used empirically as hypoglycemic medicine.Objectives: to compare the effect of Physalis minina, Linn., Psidium guajava, Linn., Sweitenia mahagoni, Jacq ethanol extract against the hypogycaemic effect of alloxan induced diabetic mice.Method: Thirty alloxan induced diabetic Swiss Webster strain mice, which fasting blood glucose level was more than 126 mg/gL, were deivided into 5 groups: each was given Physalis minina, Linn. Ethanol extract 1574,9 mg/kgBB mencit, gom arab 1% and glibenklamid 1,3 mg/kgBB for 7 days. The fasting glucose level of thosemice was measured on the eighth day. The data were analyzed using ANOVA and continued with Tukey HSD test.Results: there was highly significant difference between fasting blood glucose decrement of Physalis minina, Linn. ethanol extract group (54,26 +- 4,617%)Psidium guajava, Linn. ethanol extract group (54,44 +- 7,338%), Sweitenia mahagoni, Jacq ethanol extract group (71,3 +- 11,80%) against negative control group (1,4017 +- 4,7456%)(p<0,01).Conclusions: Physalis minina, Linn., Psidium guajava, Linn., Sweitenia mahagoni, Jacq ethanol extract can decrease blood glucose level of mice which were induced by alloxan, Sweitenia mahagoni, Jacq ethanol extract has the best effect