Tumor morphology and bones metastasis—correlation in metastatic breast carcinoma

Author: Aurelija Kizalaitė Tittle: Tumor morphology and bones metastasis—correlation in metastatic breast carcinoma Purpose: Estimate the link between bones metastasis and tumor morphology (estrogen, progesterone, human epidermal growth factor2 receptor expression) in patients with metastatic breast cancer. Objectives: 1. To determine the prevalence of skeletal metastasis among patients with metastatic breast cancer. 2. To ascertain the connection between bone metastasis and hormones (estrogen and progesterone) receptors expression. 3. To ascertain the link between bones metastasis and HER2 receptors expression. Methods: Retrospective study of medical documentation of patients with metastatic breast cancer treated in the Hospital of Lithuanian University of Health Sciences Kaunas Clinics Oncology clinic during the period of time between 2014 and 2016. In examination were included 22 patients with metatatic breast cancer and metastasis in bones. Average age of patients was 55±1,9 years, the youngest being 39 and the oldest – 71 years old. Histological and instrumental examinations’ results (MRI, CT, PET/CT) in patients’ medical records were analyzed. Results: Breast cancer metastases in bones were diagnosed in 37% patients. Positive hormones (estrogen and progesterone) receptors correlates with bones metastasis. By performing imunohistochemical test, hormones receptors were diagnosed in 72,7% patients, however this feature expression is not statistically significant (p>0,05). Negative human epidermal growth factor 2 receptors correlates with bones metastasis, human epidermal growth factor 2 receptors were diagnosed in 81,87% patients