Positive end-exipratory pressure variation effect on oxygenation for patient with mechanical ventilation

Aim of the study: To evaluate positive end-expiratory pressure (PEEP) variation effect on oxygenation for patients with mechanical ventilation. Research goals: 1. To evaluate changes in oxygenation before and after the increas of positive end-expiratory pressure. 2. To evaluate the connection between patients breathing, blood gas and blood flow indicators. Research methods: The prospective method was applied. Information of 20 patients was analyzed. Arterial blood gas was evaluated before and after PEEP increase by 2 cmH2O. The participants of research: Patients who appears in intensive care unit and are connected to mechanical ventilation and do not have acute respiratory distress syndrome. Results: All 11 women (55%) and 9 men (45%) data where evaluated. Age median was 72 years. Average FiO2 of 50% was given and initial PEEP was 5 cmH2O. 12 patients (60%) had respiratory infections, 6 (30%) had abdominal infections and 2 (10%) had other infections. When PEEP was increased by 2 cmH2O PO2 rose from 92,5 mmHg to 104 mmHg, PCO2 dropped from 34 mmHg to 33 mmHg, SpO2 increased from 97,3% to 97,5%. 7 patients PO2 didn‘t change or even decreased. The main difference between increased and decreased groups was respiratory rate: 16 k/min (16-17) vs 20 k/min (18-21), p=0,021. Conclusions: After increasing PEEP by 2 cmH2O arterial blood oxygenation indicators improved. It was observed on 13 patients’ data. For 7 patients oxygenation didn’t change or even became worse. The main difference between these two groups was respiratory rate which had a statistically significant difference