The Significance of high frequency ultrasound and immunohistochemical markers for diagnosis of melanocytic skin tumours

[...]. Aim and objectives. The aim of the study. To evaluate the significance off high-frequency ultrasound and immunohistochemical markers for the diagnosis of melonocytic skin tumours (melanoma and its precursors melanocytic nevi). The objectives of the study. 1. To compare the relationship between the results of high-frequency ultrasound (assessed manually and automatically) and histology in measuring the thickness of melanocytic skin tumours. 2. To estimate the correspondence of the features (structure, borders, boundary between the tumour and surrounding tissues) in B-scan ultrasound image to histological structure of melanocytic skin tumours. 3. To assess the significance of immunohistochemical markers (S100 and a combination of HMB-45, Melan-A and tyrosinase) for the estimation of the thickness and morphological features of melanocytic skin tumours, in comparison with conventional HE staining. [...]