Influence of Ethanol Extract of Binahong (Anredera Cordifolia (Ten.)Steenis) Leaves on Renal Failure Rat Model

Introduction: Binahong (Anredera cordifolia (Ten.) Steenis) leaves, traditionally, are used to treat various diseases including improvement renal failure.Objective: This study aims to determine the effect of binahong leaves extract to imporve renal function in renal failure conditions.Methods: The reseach includes quality analysis and testing of the effects of binahong leaves extract to renal failure. The ethanol extract of "binahong" leaves were tested on renal failure female Wistar rats induced by gentamycin at a dose of 100mg/kg bw intraperitoneally and captopril at a dose of 10 mg/kg bw orally with blood creatininelevel as parameter.Result: the research showed that the ethanol extract of "binahong" leaves a a dose of 50; 100 and 200 mg/kg bw could repair renal function showed by lowering creatinine level significantly different compared to control group (p<0.05). Bowman capsulle and glomerullus cell were recovered by the extract according to histopathology examination.Conclusion: Ethanol extract of binahong leaves can be used to improve renal failure in rats