Red blood cell eicosapentaenoic acid inversely relates to MRI-assessed carotid plaque lipid core burden in elders at high cardiovascular risk
- Bargallo, Nuria
- Gilabert, Rosa
- Romero-Mamani, Edwin-Saúl
- Cofán, Montserrat
- Calder, Philip C.
- Fitó Colomer, Montserrat
- Corella, Dolores
- Salas-Salvadó, Jordi
- Ruiz-Canela, Miguel
- Estruch, Ramón
- Ros, Emilio
- Sala Vila, Aleix
DOIAbstract
Supplemental marine omega-3 eicosapentaenoic acid (EPA) has an anti-atherosclerotic effect. Clinical research on EPA supplied by the regular diet and atherosclerosis is scarce. In the framework of the PREvención con DIeta MEDiterránea (PREDIMED) trial, we conducted a cross-sectional study in 161 older individuals at high vascular risk grouped into different stages of carotid atherosclerosis severity, including those without ultrasound-detected atheroma plaque (n = 38), with plaques <2.0 mm thick (n = 65), and with plaques ≥2.0 mm (n = 79). The latter were asked to undergo contrast-enhanced 3T magnetic resonance imaging (MRI) and were subsequently grouped into absence (n = 31) or presence (n = 27) of MRI-detectable plaque lipid, a main featu...
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