The M2-1 protein of respiratory syncytial virus (RSV) is essential for viral transcription. Previous reports suggested that dynamic regulation of M2-1 phosphorylation is critical for its function. M2-1 phosphorylation depends on the presence of the RSV phosphoprotein P, which is a multifunctional protein and the main cofactor of the large RNA polymerase L protein; formation of the P-M2-1 complex is required for viral transcription. However mechanisms involved in M2-1 phosphorylation and dephosphorylation in vivo have not been clarified. Using site-directed mutagenesis and NMR, we identified an RVxF-like motif located upstream of the M2-1 binding domain and involved in the capture of the host cell protein phosphatase-1 (PP1) by P and its rec...
Respiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cofactor of...
<div><p>Respiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cof...
Human respiratory syncytial virus (RSV) is a globally prevalent negative-stranded RNA virus, which c...
Expressing and multiplying – viral gene expressionExpressing and multiplying – viral gene expression...
Expressing and multiplying – viral gene expressionThe M2-1 protein of respiratory syncytial virus (R...
Expressing and multiplying – viral gene expressionExpressing and multiplying – viral gene expression...
Expressing and multiplying – viral gene expressionExpressing and multiplying – viral gene expression...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
<div><p>Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs)...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cofactor of...
<div><p>Respiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cof...
Human respiratory syncytial virus (RSV) is a globally prevalent negative-stranded RNA virus, which c...
Expressing and multiplying – viral gene expressionExpressing and multiplying – viral gene expression...
Expressing and multiplying – viral gene expressionThe M2-1 protein of respiratory syncytial virus (R...
Expressing and multiplying – viral gene expressionExpressing and multiplying – viral gene expression...
Expressing and multiplying – viral gene expressionExpressing and multiplying – viral gene expression...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
<div><p>Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs)...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs) in whic...
Respiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cofactor of...
<div><p>Respiratory syncytial virus (RSV) protein M2-1 functions as an essential transcriptional cof...
Human respiratory syncytial virus (RSV) is a globally prevalent negative-stranded RNA virus, which c...