New scheme of intermittent benznidazole administration in patients chronically infected with Trypanosoma cruzi. A pilot short-term follow-up study in adult patients
- Álvarez, María Gabriela
- Hernández, Yolanda
- Bertocchi, Graciela
- Fernández, Marisa Mariel
- Lococo, Bruno
- Ramirez Gomez, Juan Carlos
- Cura, Carolina Inés
- Lopez Albizu, Constanza
- Schijman, Alejandro Gabriel
- Abril, Marcelo
- Sosa-Estani, Sergio Alejandro
- Viotti, Rodolfo Jorge
DOIAbstract
There is a clinical need to test new schemes of benznidazole administration that are expected to be at least as effective as the current therapeutic scheme but safer. This study assessed a new scheme of benznidazole administration in chronic Chagas disease patients. A pilot study with intermittent doses of benznidazole at 5 mg/kg/day in two daily doses every 5 days for a total of 60 days was designed. The main criterion of response was the comparison of quantitative PCR (qPCR) findings prior to and 1 week after the end of treatment. The safety profile was assessed by the rate of suspensions and severity of adverse effects. Twenty patients were analyzed for safety, while qPCR was tested for 17 of them. The average age was 43 ± 7.9 years; 55%...
Add to ORKG