Characterization, dissolution and in vivo evaluation of solid acetazolamide complexes
- Mora, Maria Julia
- Tartara, Luis Ignacio
- Onnainty, Renée
- Palma, Santiago Daniel
- Longhi, Marcela Raquel
- Granero, Gladys Ester
DOIAbstract
The effects of binary and ternary systems of acetazolamide (ACZ) with hydroxypropyl-β-cyclodextrin (HP-β-CD) alone or with triethanolamine (TEA) on the crystalline properties, dissolution and intraocular pressure (IOP)-lowering effect were investigated. It was found that the crystal structure of ACZ powder could be modified by the processing conditions. Freeze-drying ACZ powder affected not only the particle morphology but also its polymorphic form and the starting ACZ was converted to pure form A upon freeze-drying treatment. Results provided by DSC/TGA, XRPD, SEM and FT-IR suggested the formation of inclusion complexes between ACZ with HP-β-CD alone or with TEA, obtained by the freeze-drying method and the conversion of the drug into the ...
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