Role of activin, inhibin and follistatin in the pathogenesis of bovine cystic ovarian disease
- Stangaferro, Matías L.
- Matiller, Valentina
- Díaz, Pablo Uriel
- Ortega, Hugo Hector
- Rey, Florencia
- Rodríguez, Fernanda Mariel
- Silva, Manuel A.
- Salvetti, Natalia Raquel
DOIAbstract
Cystic ovarian disease (COD) is an important cause of infertility in dairy cattle. Although many researchers have focused their works on the endocrine changes related with this disease, there is evidence that intra-ovarian components play an important role in follicular persistence. Activin, inhibin, and follistatin participate as intraovarian regulatory molecules involved in follicular cell proliferation, differentiation, steroidogenesis, oocyte maturation and corpus luteum function. Given the importance of these factors in folliculogenesis, we examined the expression and immunolocalization of activin-inhibin-follistatin system in control ovaries under estrous synchronized, adrenocorticotropin hormone (ACTH)-induced heifers and spontaneous...
Add to ORKG