Regulatory cells induced by acute toxoplasmosis prevent the development of allergic lung inflammation
- Fenoy, Ignacio Martín
- Sánchez, Vanesa Roxana
- Soto, Ariadna Soledad
- Picchio, Mariano Sergio
- Maglioco, Andrea Florencia
- Corigliano, Mariana Georgina
- Dran, Graciela Isabel
- Martín, Valentina
- Goldman, Alejandra
DOIAbstract
The increased prevalence of allergies in developed countries has been attributed to a reduction of some infections. Supporting epidemiological studies, we previously showed that both acute and chronic Toxoplasma gondii infection can diminish allergic airway inflammation in BALB/c mice. The mechanisms involved when sensitization occurs during acute phase would be related to the strong Th1 response induced by the parasite. Here, we further investigated the mechanisms involved in T. gondii allergy protection in mice sensitized during acute T. gondii infection. Adoptive transference assays and ex vivo co-cultures experiments showed that not only thoracic lymph node cells from infected and sensitized mice but also from non-sensitized infected an...
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