Synthesis of novel biaryl derivatives of sesamol (5-Benzodioxolol) and evaluation of their antioxidant activity against DPPH radical
- Rodríguez, Sergio Antonio
- Nazareno, Mónica Azucena
- Baumgartner, Maria Teresa del V.
DOIAbstract
A simple and direct arylation of sesamol with aryl halides by a photoinduced reaction is reported. Five 6-arylsesamol derivatives were synthesized in order to evaluate possible changes in their antioxidant properties as a function of the C6 aryl substituent nature. Extension of the procedure to the reaction with o-dihalobenzenes leads to the synthesis of ring-closure products bearing a tetracyclic aromatic condensed ring system, although in lower overall yields (~45 %). The antioxidant activity of the synthetic derivatives towards 1,1-diphenyl-2-picrylhydrazyl radical was determined taking sesamol as the reference compound. In addition, the relationship between the antiradical activities of these molecules against this radical and the bond ...
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