Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistance among pathogenic microorganisms. The need to overcome these deficiencies has triggered exploration for novel and unconventional approaches to controlling microbial infections. Multidrug efflux systems (MES) have been a profound obstacle in the successful deployment of antimicrobials. The discovery of small molecule efflux system blockers has been an active and rapidly expanding research discipline. A major theme in this platform involves efflux pump inhibitors (EPIs) from natural sources. The discovery methodologies and the available number of natural EPI-chemotypes are increasing. Advances in our understanding of microbial physiology have ...
Introduction: with the continuous emergence of pathogenic resistance to conventional drugs through e...
International audienceIntroduction: Worrying levels of bacterial resistance have been reported world...
WOS: 000355774200015PubMed ID: 26167829The process of active efflux, the last described resistance m...
Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistanc...
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorr...
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorr...
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of...
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of...
International audienceAfter several decades of continuously successful antibiotic therapy against ba...
An effective response that combines prevention and treatment is still the most anticipated solution ...
Introduction: Microbial resistance against antibiotics is a serious threat to the effective treatmen...
Antibiotic resistance is one of the most pressing health issues of our days. It can arise due to a m...
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due to...
Pseudomonas aeruginosa is an opportunistic human pathogen and one of the leading causes of nosocomia...
Multidrug-resistant Gram-negative bacteria pose a serious threat to human and animal health. Molecul...
Introduction: with the continuous emergence of pathogenic resistance to conventional drugs through e...
International audienceIntroduction: Worrying levels of bacterial resistance have been reported world...
WOS: 000355774200015PubMed ID: 26167829The process of active efflux, the last described resistance m...
Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistanc...
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorr...
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from the incorr...
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of...
The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the discovery of...
International audienceAfter several decades of continuously successful antibiotic therapy against ba...
An effective response that combines prevention and treatment is still the most anticipated solution ...
Introduction: Microbial resistance against antibiotics is a serious threat to the effective treatmen...
Antibiotic resistance is one of the most pressing health issues of our days. It can arise due to a m...
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due to...
Pseudomonas aeruginosa is an opportunistic human pathogen and one of the leading causes of nosocomia...
Multidrug-resistant Gram-negative bacteria pose a serious threat to human and animal health. Molecul...
Introduction: with the continuous emergence of pathogenic resistance to conventional drugs through e...
International audienceIntroduction: Worrying levels of bacterial resistance have been reported world...
WOS: 000355774200015PubMed ID: 26167829The process of active efflux, the last described resistance m...