Maternal sucrose-rich diet and fetal programming: changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis in adult offspring
- D'alessandro, Maria Eugenia Guadalupe
- Oliva, Maria Eugenia
- Fortino, María Alejandra
- Chicco, Adriana Graciela
DOIAbstract
Nutritional insults during pregnancy and lactation (P+L) are often associated with offspring health risks. We investigated the effect of maternal exposure to a sucrose-rich diet (SRD) during P+L on glucose and lipid metabolism of adult offspring regardless of post-weaning diet. Dams were fed an SRD or a control diet (CD) during P+L. After weaning, male offspring from SRD and CD dams were divided in two groups and fed a CD or SRD until 150-days old forming CD-CD, CD-SRD, SRD-SRD and SRD-CD groups. Offspring where SRD was fed at any period of life showed: 1) Increased adipose tissue weight without changes in final body weight; 2) Dyslipidemia as result of increased very low density lipoprotein triglyceride secretion rate and decreased triglyc...
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