Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
- Bermejo, Daniela Andrea
- Jackson, Shaun W.
- Gorosito Serran, Melisa
- Acosta Rodriguez, Eva Virginia
- Amezcua Vesely, Maria Carolina
- Sather, Blythe D.
- Singh, Akhilesh K.
- Khim, Socheath
- Mucci, Juan Sebastián
- Liggitt, Denny
- Campetella, Oscar Eduardo
- Oukka, Mohamed
- Gruppi, Adriana
- Rawlings, David J.
DOIAbstract
Here we identified B cells as a major source of rapid, innate-like production of interleukin 17 (IL-17) in vivo in response to infection with Trypanosoma cruzi. IL-17+ B cells had a plasmablast phenotype, outnumbered cells of the TH17 subset of helper T cells and were required for an optimal response to this pathogen. With both mouse and human primary B cells, we found that exposure to parasite-derived trans-sialidase in vitro was sufficient to trigger modification of the cell-surface mucin CD45, which led to signaling dependent on the kinase Btk and production of IL-17A or IL-17F via a transcriptional program independent of the transcription factors RORγt and Ahr. Our combined data suggest that the generation of IL-17+ B cells may be a pre...
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