Pleiotropic effects of 5-aminolevulinic acid in mice brain
- Lavandera, Jimena Veronica
- Rodriguez, Jorge
- Ruspini, Silvina Fernanda
- Meissl, Roberto Jose
- Zuccoli, Johanna Romina
- Martinez, Maria del Carmen
- Gerez, Esther Noemi
- Batlle, Alcira María del C.
- Buzaleh, Ana Maria
DOIAbstract
5-Aminolevulinic acid (ALA) seems to be responsible for the neuropsychyatric manifestations of Acute Intermittent Porphyria (AIP). The aim was to study the effect of ALA on different metabolisms in mice brain to enhance our knowledge about the action of this heme precursor on the central nervous system. Heme metabolism, cholinergic system, defense enzyme system and nitric oxide metabolism were evaluated in encephalon mice receiving a single (40 mg/kg) or multiple doses of ALA (40 mg/kg, 14 days). We have found ALA accumulation in encephalon. ALA also altered the brain cholinergic system. After one dose of ALA, a decrease in Superoxide dismutase activity and a reduction of glutathione levels were detected, while malondialdehyde levels and Ca...
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