Safety and immunogenicity of a soluble native Neospora caninum tachyzoite-extract vaccine formulated with a soy lecithin/β-glucan adjuvant in pregnant cattle
- Mansilla, Florencia Celeste
- Moore, Dadin Prando
- Quintana, Maria Eugenia
- Cardoso, Nancy Patricia
- Hecker, Yanina Paola
- Gual, Ignacio
- Czepluch, Wenzel
- Odeón, Anselmo Carlos
- Capozzo, Alejandra Victoria
DOIAbstract
The global economic impact of Neospora caninum infection in cattle herds has promoted the development of vaccines that can be safely used during pregnancy. The aim of this study was to evaluate the safety and immunogenicity of a vaccine formulated with the soluble fraction of tachyzoite's lysate and a soy-based aqueous adjuvant (sNcAg/AVEC), which was protective in the mouse model and induced strong IFN-γ responses and high avidity antibodies in non-pregnant cattle. Ten pregnant heifers were vaccinated twice during the first trimester of gestation and 8 remained unvaccinated. Anti- N. caninum immune responses were efficiently primed by vaccination, evidenced by a quick induction of IgM serum titers (7. dpv) and a prompt switch to high avidi...
Add to ORKG