Studies of ciprofloxacin encapsulation on alginate/pectin matrixes and its relationship with biodisponibility
- Islan, German Abel
- Perez de Berti, Ignacio Omar
- Marchetti, Sergio Gustavo
- Castro, Guillermo Raul
DOIAbstract
Screening of ciprofloxacin (Cip) with selected biopolymers brings about 90% antibiotic interactions with a coacervate composed of alginate/high metoxylated pectin in 2:1 ratio. Fourier transform infrared spectroscopy analysis provides information about the nature of this interaction, revealing ionic and hydrophobic patterns among the molecules. Alginate/ high methoxylated pectin gel microspheres developed by ionic gelation encapsulates 46.8± 5.0% Cip. The gel matrix can release Cip in a sustained manner, releasing 42.7±0.2% in 2 h under simulated stomach pH conditions, and 83.3±1.1% Cip release in 80 mM phosphate at pH07.40 (intestinal). The increase of sodium chloride from 50 to 200 mM implies a Cip release from 69.0±1.5% to 95.1±3.6% resp...
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