Modulation of Nitro-fatty acid signaling: prostaglandin reductase-1 is a Nitroalkene reductase
- Vitturi, Dario A.
- Chen, Chen Shan
- Woodcock, Steven R.
- Salvatore, Sonia R.
- Bonacci, Gustavo Roberto
- Koenitzer, Jeffrey R.
- Stewart, Nicolas A.
- Wakabayashi, Nobunao
- Kensler, Thomas W.
- Freeman, Bruce A.
- Schopfer, Francisco J.
DOIAbstract
Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.Fil: Vitturi, Dario A.. University of Pittsburgh; Estados UnidosFil: Chen, Chen Shan. University of Pittsburgh; Estados UnidosFil: Woodcock, Steven R.. University of Pittsburgh; Estados UnidosFil: Salvatore, Sonia R.. University of Pittsburgh; Estados UnidosFil: Bonacci, Gustavo R...
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