Consequences of excessive plasticity in the hippocampus induced by perinatal asphyxia
- Saraceno, Gustavo Ezequiel
- Cáceres, Lucila Guadalupe
- Guelman, Laura Ruth
- Castilla, Rocio Soledad
- Udovin, Lucas
- Ellisman, M. H.
- Brocco, Marcela Adriana
- Capani, Francisco
DOIAbstract
Perinatal asphyxia (PA) is one of the most frequent risk factors for several neurodevelopmental disorders (NDDs) of presumed multifactorial etiology. Dysfunction of neuronal connectivity is thought to play a central role in the pathophysiology of NDDs. Because underlying causes of some NDDs begin before/during birth, we asked whether this clinical condition might affect accurate establishment of neural circuits in the hippocampus as a consequence of disturbed brain plasticity. We used a murine model that mimics the pathophysiological processes of perinatal asphyxia. Histological analyses of neurons (NeuN), dendrites (MAP-2), neurofilaments (NF-M/Hp) and correlative electron microscopy studies of dendritic spines were performed in Stratum ra...
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