Rapid identification of OXA-48 and OXA-163 subfamily in carbapenem resistant gram-negative bacilli with a novel immunochromatographic lateral flow assay
- Pasteran, Fernando
- Denorme, Laurence
- Ote, Isabelle
- Gómez, Sonia Alejandra
- de Belder, Denise Gisele
- Glupczynsk, Youri
- Bogaerts, Pierre
- Ghiglione, Barbara
- Power, Pablo
- Mertens, Pascal
- Corso, Alejandra
DOIAbstract
We assessed a novel immunochromatographic lateral flow assay for direct identification of OXA-48-like carbapenemases and accurate differentiation of allele variants with distinct substrate profiles (OXA-48 or OXA-163 subfamilies). The assay allowed rapid (less than 4 min) and reliable direct confirmation of OXA-163- and/or OXA-48-like enzymes (with 100% sensitivity and 100% specificity) from cultured colonies that were recovered from both solid medium and spiked blood culture bottles.Fil: Pasteran, Fernando. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas. Área de Antimicrobianos; ArgentinaFil: Denorme, Laurence. Coris BioConcept...
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