Chlorpyrifos inhibits cell proliferation through ERK1/2 phosphorylation in breast cancer cell lines
- Ventura, Clara
- Venturino, Andres
- Miret, Noelia Victoria
- Randi, Andrea Silvana
- Rivera, Elena Susana
- Nuñez, Mariel
- Cocca, Claudia Marcela
DOIAbstract
It is well known the participation of oxidative stress in the induction and development of different pathologies including cancer, diabetes, neurodegeneration and respiratory disorders among others. It has been reported that oxidative stress may be induced by pesticides and it could be the cause of health alteration mediated by pollutants exposure. Large number of registered products containing chlorpyrifos (CPF) is used to control pest worldwide. We have previously reported that 50 μM CPF induces ROS generation and produces cell cycle arrest followed by cell death. The present investigation was designed to identify the pathway involved in CPF-inhibited cell proliferation in MCF-7 and MDA-MB-231 breast cancer cell lines. In addition, we det...
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