Alterations in oxidative, inflammatory and apoptotic events in short-lived and long-lived mice testes
- Matzkin, Maria Eugenia
- Miquet, Johanna Gabriela
- Fang, Yimin
- Hill, Cristal Monique
- Turyn, Daniel
- Calandra, Ricardo Saul
- Bartke, Andrzej
- Frungieri, Monica Beatriz
DOIAbstract
Aged testes undergo profound histological and morphological alterations leading to a reduced functionality. Here, we investigated whether variations in longevity affect the development of local inflammatory processes, the oxidative state and the occurrence of apoptotic events in the testis. To this aim, well-established mouse models with delayed (growth hormone releasing hormone-knockout and Ames dwarf mice) or accelerated (growth hormone-transgenic mice) aging were used. We hereby show that the testes of short-lived mice show a significant increase in cyclooxygenase 2 expression, PGD2 production, lipid peroxidation, antioxidant enzymes expression, local macrophages and TUNEL-positive germ cells numbers, and the levels of both pro-caspase-3...
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