Chronic blockade of the AT2 receptor with PD123319 impairs insulin signaling in C57BL/6 mice
- Muñoz, Marina Cecilia
- Burghi, Valeria
- Miquet, Johanna Gabriela
- Cervino,
- Quiroga, D.T.
- Mazziotta, Lucía
- Dominici, Fernando Pablo
DOIAbstract
The renin-angiotensin system modulates insulin action. Angiotensin type 1 receptor exerts a deleterious effects while the angiotensin type 2 receptor (AT2R) appears to have beneficial effects providing protection against insulin resistance and type 2 diabetes. Although recent reports indicate that agonism of AT2R ameliorates diabetes and insulin resistance, the phenotype of AT2R-knockout mice seems to be controversial relating this aspect. Thus, in this study we have explored the role of AT2R in the control of insulin action. To that end, C57Bl/6 mice were administered the synthetic AT2R antagonist PD123319 for 21 days (10 mg/kg/day ip); vehicle treated animals were used as control. Glucose tolerance, metabolic parameters, in vivo insulin s...
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