The unique architecture of the active site of Thermobifida fusca truncated hemoglobin (Tf-trHb) and other globins belonging to the same family has stimulated extensive studies aimed at understanding the interplay between iron-bound ligands and distal amino acids. The behavior of the heme-bound hydroxyl, in particular, has generated much interest in view of the relationships between the spin-state equilibrium of the ferric iron atom and hydrogen-bonding capabilities (as either acceptor or donor) of the OH− group itself. The present investigation offers a detailed molecular dynamics and spectroscopic picture of the hydroxyl complexes of the WT protein and a combinatorial set of mutants, in which the distal polar residues, TrpG8, TyrCD1, and T...
AbstractMolecular dynamics simulations, low temperature visible absorption spectroscopy, and resonan...
Molecular dynamics simulations, low temperature visible absorption spectroscopy, and resonance Raman...
Hemoglobins are a structurally diverse class of proteins with roles in biological ligand sensing, si...
International audienceThe unique architecture of the active site of Thermobifida fusca truncated hem...
The unique architecture of the active site of Thermobifida fusca truncated hemoglobin (Tf-trHb) and ...
The unique architecture of the active site of Thermobifida fusca truncated hemoglobin (Tf-trHb) and ...
The ferric form of truncated hemoglobin II from Thermobifida fusca (Tf-trHb) and its triple mutant W...
International audienceThe ferric form of truncated hemoglobin II from Thermobifida fusca (Tf-trHb) a...
The ferric form of truncated hemoglobin II from Thermobifida fusca (Tf-trHb) and its triple mutant W...
International audienceThe ferric form of truncated hemoglobin II from Thermobifida fusca (Tf-trHb) a...
The structural and functional properties of the active site of the bacterial hemoglobin from Thermob...
The structural and functional properties of the active site of the bacterial hemoglobin from Thermob...
The structural and functional properties of the active site of the bacterial hemoglobin from Thermob...
An acidic surface variant (ASV) of the "truncated" hemoglobin from Thermobifida fusca was designed w...
The crystallographic structure of oxygenated trHbN from Mycobacterium tuberculosis showed an extende...
AbstractMolecular dynamics simulations, low temperature visible absorption spectroscopy, and resonan...
Molecular dynamics simulations, low temperature visible absorption spectroscopy, and resonance Raman...
Hemoglobins are a structurally diverse class of proteins with roles in biological ligand sensing, si...
International audienceThe unique architecture of the active site of Thermobifida fusca truncated hem...
The unique architecture of the active site of Thermobifida fusca truncated hemoglobin (Tf-trHb) and ...
The unique architecture of the active site of Thermobifida fusca truncated hemoglobin (Tf-trHb) and ...
The ferric form of truncated hemoglobin II from Thermobifida fusca (Tf-trHb) and its triple mutant W...
International audienceThe ferric form of truncated hemoglobin II from Thermobifida fusca (Tf-trHb) a...
The ferric form of truncated hemoglobin II from Thermobifida fusca (Tf-trHb) and its triple mutant W...
International audienceThe ferric form of truncated hemoglobin II from Thermobifida fusca (Tf-trHb) a...
The structural and functional properties of the active site of the bacterial hemoglobin from Thermob...
The structural and functional properties of the active site of the bacterial hemoglobin from Thermob...
The structural and functional properties of the active site of the bacterial hemoglobin from Thermob...
An acidic surface variant (ASV) of the "truncated" hemoglobin from Thermobifida fusca was designed w...
The crystallographic structure of oxygenated trHbN from Mycobacterium tuberculosis showed an extende...
AbstractMolecular dynamics simulations, low temperature visible absorption spectroscopy, and resonan...
Molecular dynamics simulations, low temperature visible absorption spectroscopy, and resonance Raman...
Hemoglobins are a structurally diverse class of proteins with roles in biological ligand sensing, si...