Synthesis and Physicochemical Properties of Polyacrylamide Nanoparticles as Photosensitizer Carriers
- Gualdesi, María Soledad
- Alvarez Igarzabal, Cecilia Ines
- Vara, Jimena
- Ortiz, Cristina Susana
DOIAbstract
At present, polyacrylamide nanoparticles are attractive to drug delivery. However, some physicochemical characteristics of these nanoparticles still need to be further improved in practice. Polyacrylamide nanoparticles with an average size of 80 nm and a zeta potential of 30 mV were synthesized and used as photosensitizer carriers. The new monobrominated derivatives and parent compounds were the photosensitizers for the photodynamic therapy loaded in the nanocarrier. The physicochemical characterization of the prepared nanoparticles, drug loading, the ability to generate singlet oxygen and chemical stability were investigated. The novel tested nanoparticles exhibited a loading percentage of between 80 and 99%, higher generation of singlet o...
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