Novel sulfamides and sulfamates derived from amino esters: Synthetic studies and anticonvulsant activity
- Villalba, Maria Luisa
- Enrique, Andrea Verónica
- Higgs, Josefina
- Castaño, Rocío A.
- Goicoechea, Sofia
- Taborda, Facundo
- Gavernet, Luciana
- Lick, Ileana Daniela
- Marder, Nora Mariel
- Bruno Blanch, Luis Enrique
DOIAbstract
We report herein the design and optimization of a novel series of sulfamides and sulfamates derived from amino esters with anticonvulsant properties. The structures were designed based on the pharmacophoric pattern previously proposed, with the aim of improving the anticonvulsant action. The compounds were obtained by a new synthetic procedure with microwave assisted heating and the use of adsorbents in the isolation process. All the derivatives showed protection against the maximal electroshock seizure test (MES test) in mice at the lowest dose tested (30 mg/kg) but they did not show significant protection against the chemical induced convulsion by pentylenetetrazole. These results verify the ability of the computational model for designin...
Add to ORKG