Biological activities of Zn(II)- S -methyl-cysteine complex as antiradical, inhibitor of acid phosphatase enzyme and in vivo antidepressant effects
- Escudero, Graciela
- Martini, Nancy
- Jori, Khalil
- Jori, Nadir
- Maresca, Nahuel Rafael
- Laino, Carlos Horacio
- Naso, Luciana Gissella
- Williams, Patricia Ana María
- Ferrer, Evelina Gloria
DOIAbstract
The antidepressant effect of simple Zn(II) salts has been proved in several animal models of depression. In this study, a coordination metal complex of Zn(II) having a sulfur containing ligand is tested as antidepressant for the first time. Forced swimming test method on male Wistar rats shows a decrease in the immobility and an increase in the swimming behavior after treatment with [Zn(S-Met)2] (S-Met=S-methyl-l-cysteine) being more effective and remarkable than ZnCl2. The thiobarbituric acid and the pyranine consumption (hydroxyl and peroxyl radicals, respectively) methods were applied to evaluate the antioxidant activity of S-Met and [Zn(S-Met)2] showing evidence of attenuation of hydroxyl but not peroxyl radicals activities. UV-vis stud...
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