Neuronal and astroglial alterations in the hippocampus of a mouse model for type 1 diabetes

Revsin, Yanina
Saravia, Flavia Eugenia
Roig, Paulina
Lima, Analia Ethel
de Kloet, E. Ronald
Homo Delarche, Francoise
de Nicola, Alejandro Federico

Open link

Publication date

March 2005

DOI

10.1016/j.brainres.2004.12.032

Publisher

Elsevier BV

ISSN

0006-8993

Journal

Brain Research

Citation count (estimate)

Abstract

The influence of diabetes mellitus on brain pathology is increasingly recognized. Previous contributions of our laboratory demonstrated in models of type 1 diabetes (nonobese diabetic and streptozotocin (STZ)-treated mice), a marked astrogliosis and neurogenesis deficit in hippocampus and increased expression of hypothalamic neuropeptides. In the present investigation, we further analyzed alterations of astroglia and neurons in the hippocampus of mice 1 month after STZ-induced diabetes. Results showed that these STZ-diabetic mice presented: (a) increased number of astrocytes positive for apolipoprotein-E (Apo-E), a marker of ongoing neuronal dysfunction; (b) abnormal expression of early gene products associated with neuronal activation, inc...