Molecular mechanisms involved in mammalian gamete fusion
- Cuasnicu, Patricia Sara
- Ellerman, Diego Andrés
- Cohen, Debora Juana
- Busso, Dolores
- Morgenfeld, Mauro Miguel
- Da Ros, Vanina Gabriela
DOIAbstract
Fusion between gametes is a key event in the fertilization process involving the interaction of specific domains of the sperm and egg plasma membranes. During recent years, efforts have been made toward the identification of the specific molecular components involved in this event. The present work will focus on the best characterized candidates for mediating gamete membrane fusion in mammals. These molecules include members of the ADAM (a disintegrin and a metalloprotease domain) family, i.e., testicular proteins fertilin alpha, fertilin beta, and cyritestin, which are thought to interact with integrins in the egg plasma membrane through their disintegrin domains, and a member of the cysteine-rich secretory proteins (CRISP) family, i.e., e...
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