Neuroprotective effects of hypothermia on synaptic actin cytoskeletal changes induced by perinatal asphyxia
- Muñiz, Javier Andrés
- Romero, Juan Ignacio
- Holubiec, Mariana Ines
- Barreto, George
- Gonzalez Santos, Janneth
- Saint Martin, Madeleine
- Blanco, Eduardo
- Cavicchia, Juan Carlos
- Castilla, Rocio Soledad
- Capani, Francisco
DOIAbstract
Cerebral hypoxia–ischemia damages synaptic proteins, resulting in cytoskeletal alterations, protein aggregation and neuronal death. In the previous works, we have shown neuronal and synaptic changes in rat neostriatum subjected to hypoxia that leads to ubi-protein accumulation. Recently, we also showed that, changes in F-actin organization could be related to early alterations induced by hypoxia in the Central Nervous System. However, little is known about effective treatment to diminish the damage. The main aim of this work is to study the effects of birth hypothermia on the actin cytoskeleton of neostriatal post-synaptic densities (PSD) in 60 days olds rats by immunohistochemistry, photooxidation and western blot. We used 2 different prot...
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